𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Fluorinated succinic acid derivatives from new refrigerants via ozonolysis of haloalkenes

✍ Scribed by Samantha J Brown; Stuart Corr; Jonathan M Percy

Book ID
104210488
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
160 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Fluoro-and di-Β―uoro allylic alcohols obtained from HFC-134a and HCFC-133a were transformed through [3,3]-sigmatropic rearrangements into 3-Β―uoro-4-halo-4-alkenoates with variable substitution at the 2-and 3-positions. Ozonolysis of the haloalkenes aorded the corresponding acyl halides which could be trapped with nucleophiles to aord Β―uorinated succinic acid derivatives in which the two carboxylic acid groups were dierentiated.

πŸ“œ SIMILAR VOLUMES

New expedient route to the stereoselecti
New expedient route to the stereoselective synthesis of fluorinated 1,3-diol derivatives via aluminum acetals derived from Ξ²-alkoxy esters and DIBAL
✍ Takashi Ishihara; Atsuya Takahashi; Hidetoshi Hayashi; Hiroki Yamanaka; Toshio K πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 228 KB

On treating the aluminum acetal intermediates, generated in situ from ethyl 3-benzyloxy-2, 2-difluoroalkanoates or 3-benzyloxy-4,4,4-trifluorobutanoate and diisobutylaluminum hydride at -78 qC for 1 h, with allylic stannanes in the presence of titanium(IV) dichloride diisopropoxide at 0 ~C for 8 h o