Fluorinated heterocyclic compounds. 2. 2,4-difluoro and 4-amino-2-fluoropyrimidines, nucleoside base analogs
β Scribed by Polina I. Svirskaya; Varda Yedidia; Clifford C. Leznoff; Jack M. Miller
- Book ID
- 112127753
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1985
- Tongue
- English
- Weight
- 362 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-152X
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Analogs of Met-enkephalin and [D-Pen 2 , D-Pen 5 ]enkephalin (DPDPE) containing the partially fluorinated amino acid 4,4-difluoro-2-aminobutyric acid (DFAB) in the 2-or 3-position of the peptide sequence were synthesized and their opioid activities and receptor selectivities were determined in vitro
Tolman and Vereg hare recently published in this Journal (1) a eynthesi~ of 4-amino-2-fluoroorotanic acid from 4-bromo-2-fluorocrotonic acid e the 4-phthalisido compound. We hare prepared the can aold by a different route, using the method of Bergpann and Shah& (2). Phthalidd-
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