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Fluoride distribution in rats during and after continuous infusion of Na18F

✍ Scribed by R.M. Knaus; F.N. Dost; D.E. Johnson; C.H. Wang

Book ID
119002288
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
620 KB
Volume
38
Category
Article
ISSN
0041-008X

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Maternal and fetal distribution of a pho
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## Abstract **BACKGROUND:** Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20‐base phosphorothioate oligonucleotide, in timed‐pregnant Sprague‐Dawley rats. **METHODS:** To maximize the potential for fetal exposure, ISIS 2105 was administer