Fluorescence, Induced Circular Dichroism and Molecular Mechanics of 1-Methyl Naphthalenecarboxylate Complexes with 2-Hydroxypropyl Cyclodextrins
✍ Scribed by María José González-Álvarez; Antonio Di Marino; Francisco Mendicuti
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 927 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1053-0509
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Molecular mechanics calculations were employed to study the inclusion of 2-methyl naphthoate in alpha- and beta-cyclodextrin in vacuo and in the presence of water as a solvent. The driving forces for complexation are dominated by nonbonded van der Waals host:guest interactions in both environments.
## Abstract The inclusion complex of heptakis(2,6‐di‐__O__‐methyl)‐β‐cyclodextrin (DIMEB) with euplotin C (EC), a cytotoxic metabolite isolated from the protistan strains composing the marine ciliate __Euplotes crassus,__ has been investigated by ^1^H NMR techniques, electrospray ionization mass sp