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Fluorescence in situ hybridization as a tool for microstaging in malignant melanoma

✍ Scribed by Newman, Marissa D; Lertsburapa, Terakeith; Mirzabeigi, Marjan; Mafee, Mariam; Guitart, Joan; Gerami, Pedram


Book ID
109887826
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
467 KB
Volume
22
Category
Article
ISSN
0893-3952

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DNA amplification is an important mechanism of tumor progression that allows cancer cells to up-regulate the expression of critical genes such as oncogenes and genes conferring drug resistance. Recent studies using comparative genomic hybridization (CGH) revealed increased DNA copies of 20q sequence