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Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors

✍ Scribed by Kernek, Kevin M; Brunelli, Matteo; Ulbright, Thomas M; Eble, John N; Martignoni, Guido; Zhang, Shaobo; Michael, Helen; Cummings, Oscar W; Cheng, Liang

Book ID: 109888041
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 155 KB
Volume: 17
Category: Article
ISSN: 0893-3952
DOI: 10.1038/modpathol.3800195

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## Abstract The i(12p) marker chromosome has been found to be a highly nonrandom chromosome abnormality associated with germ cell tumors (GCTs). We have previously shown that a chromosome 12 centromere specific α‐satellite DNA probe detects the i(12p) by virtue of differences in the size of the sig