Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced Protoporphyrin IX for the dectection of neoplastic lesions in the oral cavity
✍ Scribed by Andreas Leunig; Kai Rick; Herbert Stepp; Ralph Gutmann; Goetz Alwin; Reinhold Baumgartner; Jens Feyh
- Book ID
- 117026149
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 525 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0002-9610
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Background and Objective: 5-Aminolevulinic acid-induced protoporphyrin IX is a promising photosensitizer that could enhance the spectroscopic contrast between normal and diseased oral tissues. Knowledge of the pharmacokinetics and effects on tissue type are important for diagnostic and therapeutic p
## Abstract ## Background and Objectives Studies of 5‐aminolevulinic acid‐induced protoporphyrin IX fluorescence have shown a sensitivity of 95–100% for oral cancer diagnosis, but the specificity is only about 50–60%. Here, we explore the applicability of quantifying PPIX fluorescence images to im
When 5-aminolevulinic acid ( ALA ) is administered topically, intravenously or intraperitoneally to tumor-bearing animals or humans, tumor selective production of protoporphyrin IX ( PpIX ) is frequently observed. Several biophysical, biochemical and physiological factors explain this tumor selectiv