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Fluorescence Detection of a Neurotoxic Astroglia-Released Factor using Gradient Liquid Chromatography after Precolumn Derivatization

✍ Scribed by Ph. Hubert; V. Hurlet; J.-M. Rigo; P. Coucke; G. Moonen; J. Crommen

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
119 KB
Volume
11
Category
Article
ISSN
0269-3879

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✦ Synopsis

Figure 1. Chromatographic profiles of the ACM preparation without addition

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## Abstract A rapid and sensitive HPLC enantioselective method with fluorescence detection was developed to determine (−)‐(__R__) and (+)‐(__S__) enantiomers of the metabolites of citalopram, demethyl‐ and didemethyl‐citalopram in plasma and brain tissue. This assay involves pre‐column chiral deriv