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Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones

โœ Scribed by M.A. Cousin; D.G. Nicholls; J.M. Pocock

Book ID
115804123
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
870 KB
Volume
606
Category
Article
ISSN
0006-8993

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## Abstract Nitric oxide (NO; 1 ฮผM) or an NO donor (500 ฮผM diethylenetriamineโ€nitric oxide, DETAโ€NONOate) caused rapid glutamate and ATP release from cultured rat cortical astrocytes. NOโ€induced glutamate release was prevented by calcium chelators (EGTA or BAPTAโ€AM) and an inhibitor of vesicular ex