## Abstract The potential of the calciumβentry blocker flunarizine in modulating the cytotoxicity of doxorubicin was investigated in human colonβadenocarcinoma cell lines sensitive to (LoVo) or with experimentally induced resistance (LoVo/DX) to doxorubicin. Exposure to 1 to 2 mΜg/ml flunarizine fo
β¦ LIBER β¦
Flunarizine and lonidamine as modulators of anticancer drug activity in human colon adenocarcinoma cells
β Scribed by Orlandl, L.; Zaffaroni, N.; Costa, A.; Villa, R.; Silvestrini, R.
- Book ID
- 123116273
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 182 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0959-8049
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The ability of lonidamine (LND), an energolytic derivative of indazole-carboxylic acid, to modulate the cytotoxicity of Taxol (TX) was investigated in the A2780 human ovarian cancer cell line. Different cytotoxicity results were obtained as a function of treatment schedule. Specifically, TX followed