Fluid mixing in shaken bioreactors: Implications for scale-up predictions from microlitre-scale microbial and mammalian cell cultures

Scale-up of bioreactors for fermentation

Scale-up of bioreactors for fermentation of mammalian cell cultures with special reference to oxygen supply and microcarrier mixing

✍ Dipl.-Ing. Jürgen Vorlop; Dr.-Ing. Jürgen Lehmann 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 631 KB

The increasing demand for products from mammalian cells has prompted the authors to develop a new type of bioreactor. Its significant features include the supply of oxygen, homogeneous distribution of microcarrier suspensions and process control. Media with high protein contents, required for mammal