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Fludarabine, cytarabine, and mitoxantrone (FLAM) for the treatment of relapsed and refractory adult acute lymphoblastic leukemia. A phase study by the Polish Adult Leukemia Group (PALG)

✍ Scribed by Sebastian Giebel; Malgorzata Krawczyk-Kulis; Maria Adamczyk-Cioch; Beata Jakubas; Grazyna Palynyczko; Krzysztof Lewandowski; Anna Dmoszynska; Aleksander Skotnicki; Katarzyna Nowak; Jerzy Holowiecki; On behalf of the Polish Adult Leukemia Group

Publisher: Springer
Year: 2006
Tongue: English
Weight: 136 KB
Volume: 85
Category: Article
ISSN: 0939-5555
DOI: 10.1007/s00277-006-0121-5

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## Abstract ## Background Homoharringtonine (HHT) is a plant alkaloid that is derived from a Chinese evergreen tree. Its mechanism of action is thought to be by inhibition of protein, DNA, and RNA synthesis by inhibition of chain initiation. The treatment of acute myelogenous leukemia (AML) in chi