Fluctuation in the concentrations of vanillylmandelic acid and homovanillic acid in mass screening for neuroblastoma
β Scribed by M. Nishi; H. Miyake; T. Takeda; K. Yamashiro; N. Takasugi; J. Hanai; T. Kawai
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 267 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0340-6997
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π SIMILAR VOLUMES
A method for the quantitative determination of homovanillic acid (HVA) and vanillylmandelic acid (VMA), two metabolites of catecholamines, is presented. The assay is based on gas chromatography/electron impact mass spectrometry. The preparation of 13C-labeled VMA from is described. Together with pur
## Abstract Recent reports have suggested that elevations of serum dopamineβBβhydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the
The plasma levels of homovanillic and vanillylmandelic acids were determined in 84 children with neuroblastoma prior to treatment to evaluate the usefulness of these parameters for the diagnosis of this disease. Elevated levels of one or both of these metabolites were observed in 50% of children wit