๐”– Bobbio Scriptorium
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Fluctuation analysis: the effect of plating efficiency

โœ Scribed by F. M. Stewart

Publisher
Springer Netherlands
Year
1991
Tongue
English
Weight
357 KB
Volume
84
Category
Article
ISSN
0016-6707

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โœฆ Synopsis

This paper supplements an earlier paper which explained how to calculate the probability distribution of the number of mutants that would be observed in a fluctuation test experiment. The formulas in that work give the distributions to be expected under a wide variety of experimental conditions, but the method it uses when only a fraction of the mutants will produce visible colonies are clumsy and inefficient. Here I describe efficient procedures for dealing with that case, provided that the mutation rate per cell division remains constant during the experiment.

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