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Fluconazol plus ofloxacin in prophylaxis of infections in patients with acute leukemia: a comparative study

✍ Scribed by P. Šajben; T. Minárik; E. Tomášik; J. Mardiak; A. Danisovičovà; T. Trupl; V. Krčméry

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
239 KB
Volume
1
Category
Article
ISSN
0941-4355

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✦ Synopsis

In a retrospective study the incidence of infections, number of afebrile days, duration of antimicrobial chemotherapy, and cost of antibacterials and antimycotics were compared in two groups of patients. One was a group of 57 patients who received no prophylaxis during induction remission therapy of acute leukemia treated in 1989-1990, the second was a group of 22 patients treated in 1991 where prophylaxis with fluconazol and ofloxacin was administered. For ethical reasons pertaining since 1991, when prophylaxis became mandatory, the study was not randomized. A decrease in the number of febrile days, the cost of antimicrobials and the duration of treatment with antibiotics and antimycotics was observed in the group receiving fluconazol and ofloxacin.

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