## Abstract Gene profiling studies of patients with chronic lymphocytic leukemia (CLL) has revealed increased expression of Ror1, a cell surface receptor tyrosine kinase. The aim of present study was to analyze gene and protein expression of Ror1 in CLL cells and normal blood leukocytes. Gene expre
β¦ LIBER β¦
FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy
β Scribed by Tomoki Naoe; Hitoshi Kiyoi; Yukiya Yamamoto; Yosuke Minami; Kazuhito Yamamoto; Ryuzo Ueda; Hidehiko Saito
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 101 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0344-5704
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## Abstract The tyrosine kinase domain (TKD) mutations of receptor tyrosine kinase CβKIT are associated with a poor prognosis in acute myeloid leukemia (AML). However, the underlying mechanisms are not fully understood. We found the activity of protein phosphatase 2A (PP2A), a human tumor suppresso