FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns
✍ Scribed by Anna Andersson; Kajsa Paulsson; Henrik Lilljebjörn; Carin Lassen; Bodil Strömbeck; Jesper Heldrup; Mikael Behrendtz; Bertil Johansson; Thoas Fioretos
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 122 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Abstract
During 1995–2004, 209 children/adolescents were diagnosed with acute lymphoblastic or myeloid leukemia (ALL, AML) in Southern Sweden, of which 177 (85%), comprising 128 B‐lineage ALL, 34 AML, and 15 T‐cell ALL, could be analyzed for internal tandem duplications (ITD) and activating point mutations in the second tyrosine kinase domain (ATKD) of FLT3. Seventeen (10%) FLT3 mutations (6 ITD, 11 ATKD; mutually exclusive) were detected. None of the T‐cell ALL harbored any mutations. ITD and ATKD were found in 2% and 6% of the B‐lineage ALL and in 12% and 9% of the AML, being particularly common in high hyperdiploid ALL (14%), ALL (20%), and AML (23%) with 11q23/MLL rearrangements, and in AML with a normal karyotype (60%). All ATKD‐positive AML with MLL rearrangements harbored the t(9;11)(p21;q23). Global gene expression data were available for 76 of the B‐lineage ALL and 19 of the AML, of which 6 (8%) and 3 (16%) had FLT3 mutations, respectively. No distinct expression pattern associated with FLT3 mutations was identified. © 2007 Wiley‐Liss, Inc.