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FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling

✍ Scribed by Akira Katsumi; Hitoshi Kiyoi; Akihiro Abe; Ryohei Tanizaki; Toshihiro Iwasaki; Miki Kobayashi; Tadashi Matsushita; Kozo Kaibuchi; Takeshi Senga; Tetsuhito Kojima; Takayuki Kohno; Michinari Hamaguchi; Tomoki Naoe

Book ID
114794879
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
310 KB
Volume
86
Category
Article
ISSN
0902-4441

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## Abstract α4β1 integrin is highly expressed in lymphocytes and is essential in hematopoiesis, extravasation, and the inflammatory response. α4β1 can be activated by intracellular signals elicited upon T‐cell activation by phorbol esters, CD3 crosslinking, or certain chemokine/receptor interaction