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Flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate–thioacetamide–sodium hexametaphosphate

✍ Scribed by Lun Wang; Bo Ling; Hongqi Chen; Ani Liang; Binbin Qian; Jie Fu

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
543 KB
Volume
25
Category
Article
ISSN
1522-7235

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✦ Synopsis

Abstract

A novel chemiluminescence method for the determination of 6‐mercaptopurine was established based on 6‐mercaptopurine inhibition of the chemiluminescence emission of potassium permanganate–thioacetamide–sodium hexametaphosphate system. The peak height was proportional to log 6‐mercaptopurine concentration in the range 7.0 × 10^−10^ to 1.0 × 10^−7^ g/mL and the detection limit was 1.9 × 10^−11^ g/mL (S/N = 3). The relative standard deviation was 1.5% for the determination of 8.0 × 10^−8^ g/mL 6‐mercaptopurine (n = 11). The proposed sensor was successfully applied to the analysis of 6‐mercaptopurine in human serum samples. Copyright © 2009 John Wiley & Sons, Ltd.

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