Flow-injection analysis for meloxicam based on tris(2,2′-bipyridine) ruthenium(II)–Ce(IV) chemiluminescent system

✍ Scribed by Huazhen Ye; Bin Qiu; Jing Chen; Jinming Lin; Guonan Chen

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 277 KB
• Volume: 24
• Category: Article
• ISSN: 1522-7235
• DOI: 10.1002/bio.1117

✦ Synopsis

Abstract

It was found that meloxicam could enhance the chemiluminescence (CL) of the tris(2,2'‐bipyridine) ruthenium(II)–Ce(IV) system in the medium of sulfate acid. Based on this phenomenon a new flow‐injection system with chemiluminescent detection has been proposed for determination of meloxicam. Under optimum conditions, meloxicam had a good linear relationship with the CL intensity in the concentration range of 6.0  10^−4^ to 1.0 µg/mL and the detection limit was 3.7 × 10^−4^µg/mL. The proposed method was applied to detect meloxicam in tablets and a satisfactory recovery was obtained. The possible mechanism for this CL system is also discussed in this paper. Copyright © 2009 John Wiley & Sons, Ltd.