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Flow-enhanced off-resonance saturation for remote detection of iron-based contrast agents

✍ Scribed by Philipp Krämer; Xavier Helluy; Thomas Kampf; Esra Lang; Peter M. Jakob

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
886 KB
Volume
63
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A switchable contrast mechanism, flow enhanced off‐resonance saturation, is presented. This technique combines the effects of flow and off‐resonance saturation for remote detection of iron oxide contrast agents incorporated into a vessel wall. Initial results from phantom experiments are presented and show the feasibility of this method. A specific saturation contrast could be observed. This contrast mechanism is highly dependent on field homogeneity and spectral selectivity of the off‐resonance saturation pulses. The contrast scales directly with the pulse offset of the used saturation pulses, the flow velocity in the vessel, and the duration of the off‐resonance saturation module prior to the imaging sequence. This technique has the potential to detect iron‐loaded atherosclerotic plaques in future in vivo applications. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.

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