Flow cytometric S-phase fraction measurement in breast carcinoma: Influence of software and histogram resolution
✍ Scribed by Marie-Lise Jourdan; Magali Ferrero-Poüs; Frédérique Spyratos; Sylvie Romain; Pierre-Marie Martin; Agnès Chassevent
- Book ID
- 102136378
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 66 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0196-4763
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S-phase fraction (SPF), estimated in the flow cytometric DNA histogram, is a prognostic factor in breast cancer. There are, however, some inherent difficulties in the estimation of SPF, such as the influence of debris, aggregates, and normal cells. Most of the available SPF calculation principles tr
## Abstract ## Background The value of flow cytometric analysis of DNA ploidy and S‐phase fraction (SPF) as an indicator of regional metastasis in oral cancer is currently being debated. Intratumoral heterogeneity makes this problem complex. ## Methods Intratumoral DNA ploidy heterogeneity and i