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Flow cytometric findings in the floral variant of follicular lymphoma

✍ Scribed by Cherie H. Dunphy; Janusz W. Wolaniuk; Ronald P. Turgeon


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
391 KB
Volume
12
Category
Article
ISSN
0887-8013

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✦ Synopsis


The floral variant of follicular lymphoma (FL-F) is an unusual variant of follicular lymphoma. The malignant "follicles" have an unusual "floral" appearance due to the proliferation of surrounding and infiltrating small lymphocytes. This variant of malignant lymphoma has been supported by immunohistochemical immunophenotyping and gene-rearrangement studies; however, the flow cytometric findings have not previously been described. We report the flow cytometric findings in two cases of FL-F. The surrounding and infiltrating small lymphocytes represented mantle cells which, in one case, obscured monoclonality in the lymphocyte region. The monoclonal B-cells were CD10+, supporting a follicular center cell origin.


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