Flow cytometric evaluation of cell-cycle progression in ethyl methanesulfonate and methyl methanesulfonate-exposed P3 Cells: Relationship to the induction of sister-chromatid exchanges and cellular toxicity

Effect of bromodeoxyuridine on the proli

Effect of bromodeoxyuridine on the proliferation and growth of ethyl methanesulfonate-exposed P3 cells: Relationship to the induction of sister-chromatid exchanges

✍ Suzanne M. Morris; Olen E. Domon; Lynda J. McGarrity; Ralph L. Kodelo; Daniel A. 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 730 KB

Although sister-chromatid exchange (SCE) analysis is recognized as an indicator of exposure to DNA-damaging agents, the results of these analyses have been confounded by the use of bromodeoxyuridine (BrdUrd) to differentially label the sister chromatids. Not only does BrdUrd itself induce SCE, it al