Tumor heterogeneity may adversely affect the flow cytometric measurement of S-phase fraction (SPF) in breast cancer specimens, and 1&20% of breast cancer specimens are not evaluable by flow cytometry due to technical factors such as debris, high coefficients of variation, poor specimen quality, or s
Flow cytometric (DNA content and S-phase fraction) analysis of breast cancer
β Scribed by John G. Batsakis; Nour Sneige; Adel K. El-Naggar
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 313 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
S-phase fraction (SPF), estimated in the flow cytometric DNA histogram, is a prognostic factor in breast cancer. There are, however, some inherent difficulties in the estimation of SPF, such as the influence of debris, aggregates, and normal cells. Most of the available SPF calculation principles tr
## Background: The authors determined the flow cytometric (fcm) dna characteristics of 53 benign tumors and 132 malignant (71 primary, 61 recurrent) soft tissue sarcomas to investigate their heterogeneity and to evaluate the prognostic values of dna ploidy status and s-phase fraction (spf). ## Met