FLK-1-based minigene vaccines induce T cell-mediated suppression of angiogenesis and tumor protective immunity in syngeneic BALB/c mice

Vaccination with dendritic cells pulsed

Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell–mediated protective immunity in Her-2/neu transgenic mice

✍ Camilo Cuadros; Ana Lucia Dominguez; Pier-Luigi Lollini; Michael Croft; Robert S 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 854 KB

## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor