Flippase Activity in Proteoliposomes Reconstituted with Spinacea oleracea Endoplasmic Reticulum Membrane Proteins: Evidence of Biogenic Membrane Flippase in Plants †

Inhibition of biogenic membrane flippase

Inhibition of biogenic membrane flippase activity in reconstituted ER proteoliposomes in the presence of low cholesterol levels

✍ Archita Rajasekharan; Sathyanarayana N. Gummadi 📂 Article 📅 2012 🏛 SP Versita 🌐 English ⚖ 948 KB

## Abstract Biogenic membranes or self-synthesizing membranes are the site of synthesis of new lipids such as the endoplasmic reticulum (ER) in eukaryotes. Newly synthesized phospholipids (PLs) at the cytosolic leaflet of ER need to be translocated to the lumen side for membrane biogenesis and this