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FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis

✍ Scribed by Ju-Eun Ha; Young-Eun Choi; Jinah Jang; Cheol-Hee Yoon; Ho-Youn Kim; Yong-Soo Bae

Book ID: 111312487
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 456 KB
Volume: 275
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1742-4658.2008.06500.x

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## Abstract ## Objective Rheumatoid arthritis (RA) is characterized by inflammation and destruction of synovial joints. Fibroblast‐like synoviocytes (FLS) harvested from synovial tissue of patients with RA can invade normal human cartilage in severe combined immunodeficient (SCID) mice and Matrige