Flexible but with a Defined Turn—Influence of the Template on the Binding Properties of Two-Armed Receptors

The influence of rigid or flexible linka

The influence of rigid or flexible linkage between two ligands on the effective affinity and avidity for reversible interactions with bivalent receptors

✍ S. A. Bobrovnik 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB

## Abstract Bivalent or polyvalent cooperative binding between ligand and receptor is much tighter and more efficient than monovalent binding of the same counterparts. Because of this, many biological processes involve polyvalent binding for realization of regulatory mechanisms. For this reason it