✦ LIBER ✦

Flexible association of hemopoietic differentiation programs in multilineage colonies

✍ Scribed by B. Lim; N. Jamal; H. A. Messner

Book ID: 102885891
Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 893 KB
Volume: 121
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041210205

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✦ Synopsis

Pluripotent hemopoietic progenitors lose potentialities during the process of differentiation. We have examined events that lead to lineage restriction by determining t h e cellular composition of 785 multilineage colonies grown from peripheral blood samples of glucose-6-phosphate-dehydrogenase (Gd-PD) heterozygous volunteers. Of these colonies, 762 contained only one isoenzyme type and were considered to be of clonal origin. A considerable heterogeneity was observed. Some colonies were composed of cells belonging to two different lineages, while other colonies contained three or more different cell types. A small number of colonies consisted-in addition to myeloid cells-of T-lymphocytes. The variable association within individual colonies of members belonging to different hemopoietic lineages suggests a flexible determination and expression of differentiation programs by early progenitors.

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