Flexibility in T-cell receptor ligand repertoires depends on MHC and T-cell receptor clonotype
โ Scribed by A. GELUK; K. E. VAN MEIJGAARDEN; T. H. M. OTTENHOFF
- Book ID
- 108781330
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 152 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0019-2805
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๐ SIMILAR VOLUMES
Antigens are presented to T cells as short peptides bound to MHC molecules on the surface of body cells. The binding between MHC/peptides and T cell receptors (TCRs) has a low affinity and is highly degenerate. Nevertheless, TCR-MHC/peptide recognition results in T cell activation of high specificit
Stimulation of T cells by the T-cell receptor (TCR)/CD3 complex results in interleukin-2 (IL-2) synthesis and surface expression of the IL-2 receptor (IL-2R), which in turn drive T-cell proliferation. However, the significance of the requirement of IL-2 in driving T-cell proliferation, when TCR stim