Fletcher factor deficiency in a 9-year-old girl: Mechanisms of the contact pathway of blood coagulation
✍ Scribed by Raul A. Dela Cadena
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 835 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
A 9-year-old black girl with a markedly prolonged (58 sec, control 28.0) activated partial thromboplastin time ( A m ) was referred to us for further evaluation and coagulation studies in preparation for a dental extraction. The patient's prothrombin time (PT) (1 1.4 sec, control 11.3) and bleeding time (6.5 min; normal 2-7) were normal. The past medical history was remarkable for premature delivery by cesarean section at 32 weeks gestation.
The neonatal period was complicated by the development of respiratory distress syndrome, intracranial hemorrhage, and seizures. The patient had undergone a Nissen fundoplication with gastrectomy tube placement and an appendectomy at 2 years of age. The surgical procedures were well tolerated without any bleeding complications. There was no family history of a bleeding disorder on the paternal side; no information was available on the maternal side. The laboratory data suggests a coagulation abnormality in the intrinsic pathway of blood coagulation.