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Fleetamine (3-O-α-d-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-α-mannosidase

✍ Scribed by Tim Quach; Sammi Tsegay; Andrew J. Thompson; Nikolay V. Kukushkin; Dominic S. Alonzi; Terry D. Butters; Gideon J. Davies; Spencer J. Williams


Book ID
119375856
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
716 KB
Volume
23
Category
Article
ISSN
0957-4166

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The uptake of swainsonine, a specific in
✍ Kokila Chotai; Christine Jennings; Bryan Winchester; Peter Dorling 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 653 KB

Swainsonine, an indolizidine alkaloid, found in plants of the genus Swainsona, has been shown to be a strong inhibitor in vitro of the a-D-mannosidase activity in normal human fibroblasts. Therefore, inhibition of a-D-mannosidase activity in extracts of harvested cells grown with swainsonine in the