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Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

✍ Scribed by Watanabe, Hiroshi; Chopra, Nagesh; Laver, Derek; Hwang, Hyun Seok; Davies, Sean S; Roach, Daniel E; Duff, Henry J; Roden, Dan M; Wilde, Arthur A M; Knollmann, Björn C


Book ID
109926172
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
397 KB
Volume
15
Category
Article
ISSN
1078-8956

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## Abstract The cardiac ryanodine receptor (RyR2), the major calcium release channel on the sarcoplasmic reticulum (SR) in cardiomyocytes, has recently been shown to be involved in at least two forms of sudden cardiac death (SCD): (1) Catecholaminergic polymorphic ventricular tachycardia (CPVT) or