Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase
β Scribed by M. Merlos; R. M. Sanchez; J. Camarasa; T. Adzet
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 392 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1420-682X
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π SIMILAR VOLUMES
Purification of glutathione S-transferases A and C from rat liver cytosol using an affinity matrix coupled with cholic acid is described. The method provides a convenient means for the rapid and homogeneous preparation of both transferases.
The in vitro interaction of the mycotoxin penicillic acid (PA) with rat liver glutathione S-transferase (GST) was studied using reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. The inhibition of the GST activity by PA in crude extracts was dose dependent. Each of the different GST