The pharmacokinetics of the novel anticancer agent, flavone acetic acid (FAA) were investigated in Balb-c mice treated with i.v. doses of 100 mg/kg or 300 mg/kg, using an HPLC assay. The kinetics of disappearance from plasma was monoexponential and dose-dependent. After 100 mg/kg, the plasma peak le
Flavone acetic acid induces a coagulopathy in mice
โ Scribed by Murray, JC; Smith, KA; Thurston, G
- Book ID
- 109836267
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 828 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0007-0920
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๐ SIMILAR VOLUMES
Flavone acetic acid pharmacokinetics were studied in 31 patients in a phase I clinical trial. The drug was given by i.v. infusions over 1, 1.5, 3, and 6 h at doses ranging from 0.5 to 6.4 g/m2. The pharmacokinetic parameters were determined according to a nonlinear model including Michaelis-Menten-t
Flavone acetic acid (FAA) is a new antitumor agent that has recently entered Phase I clinical trials. In preclinical studies, we have found that FAA was broadly active against a variety of transplantable solid tumors of mice (colon # 51, #07, # 10, #26; pancreatic ductal adenocarcinomas #02 and #03;