Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumours

Selective induction of endothelial cell

Selective induction of endothelial cell tissue factor in the presence of a tumour-derived mediator: A potential mechanism of flavone acetic acid action in tumour vasculature

✍ J. Clifford Murray; Matthias Clauss; Juliana Denekamp; David Stern 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 747 KB

Flavone acetic acid (FAA) is a potentially useful antitumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulan