Flame control accessory for GC-FID operation with autosampler injection
✍ Scribed by Helmig, Detlev ;Schwarzer, Norbert ;Steinhanses, Jürgen
- Book ID
- 102348369
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 292 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0935-6304
No coin nor oath required. For personal study only.
✦ Synopsis
of 79LN35R.D i I I ( b ) 5 10 15 20 25 Time ( m i n . ) Figure 4 HPLC chromatograms of degraded Nicardipine samples ( 2 mg/ml in mobile phase): (a) after three weeks under daylight and at room temperature; (b) after three months at 50 "C; (c) control sample.
4 Conclusions
This work describes a chromatographic method which is applicable to the quantitation of Nicardipine and its related compounds (present as minor impurities). Although the method is simple, and requires neither derivatization nor sophisticated apparatus, the chromatographic parameters must be set with care. The system suitability test should be run before each analysis to guard against deviation from the original conditions.
Both assay and purity methods have been shown to be good indicators of stability. The method is being applied to samples prepared from raw materials and excellent results have been obtained.