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FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A

✍ Scribed by Periyasamy, S; Hinds, T; Shemshedini, L; Shou, W; Sanchez, E R

Book ID
109971231
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
772 KB
Volume
29
Category
Article
ISSN
0950-9232

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## Abstract The androgen receptor (AR) is a ligand‐dependent transcription factor belonging to the steroid hormone receptor superfamily. Under normal conditions, in the absence of a ligand, the AR is localized to the cytoplasm and is actively transported into the nucleus upon binding of androgens.