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FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes

✍ Scribed by Takaya Yamagami; Yuko Waguri-Nagaya; Kenji Ikuta; Mineyoshi Aoyama; Kiyofumi Asai; Takanobu Otsuka

Publisher: Springer
Year: 2010
Tongue: English
Weight: 261 KB
Volume: 31
Category: Article
ISSN: 0172-8172
DOI: 10.1007/s00296-010-1411-8

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## Objective: To investigate the effects of the antiinflammatory cytokines interleukin-4 (il-4), il-10, and il-13 on tumor necrosis factor alpha (tnfalpha)-induced prostaglandin e2 (pge2) release in the cellular signaling cascade on human osteoarthritis (oa) synovial fibroblasts. ## Methods: Huma