Structural Investigations of 13-O-Demeth
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Wolfgang SchΓΌler; P. Schmieder; Horst Kessler; Uwe Christians; Ines Holze; Karl-
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Article
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1993
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John Wiley and Sons
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German
β 775 KB
FK506 is currently under investigation as immunosuppressant after organ transplantation and in immune diseases. The structure of a demethylated metabolite 1 of FK506 isolated after in oitro metabolism by human-liver microsomes was established using two-dimensional homo-and heteronuclear NMR experime