FK 506–A promise of good things to come?

✍ Scribed by James Neuberger

• Book ID: 102238720
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 262 KB
• Volume: 13
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840130638

✦ Synopsis

HEPATOLOGY Elsewhere 1259

nisms that may reflect in part its hydrophilicity. The issue, however, would seem more complex, in that increasing hydrophilicity alone (i.e., with taurine conjugation) does not enhance the clinical response to UDCA. Additional answers may come from understanding how UDCA affects BA absorption in the intestine, BA secretion by the hepatocyte, membrane toxicity and MHC-antigen expression.

We are only beginning to understand the complex intricacies of UDCA and the liver, and it is hoped this line of research will provide us with more nontoxic, efficacious therapies for cholestatic liver disease.