Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel
✍ Scribed by C-Y. Chu; C-H. Yang; C-Y. Yang; G-H. Hsiao; H-C. Chiu
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 482 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0007-0963
No coin nor oath required. For personal study only.
✦ Synopsis
Docetaxel (Taxotere), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.