✦ LIBER ✦
Fixation of pharmacologically active amines on polyphosphonates, 3. Synthesis and preliminary in vitro cytotoxic studies of bis(2-chloroethyl)amino group containing polyphosphonates
✍ Scribed by Laurent Fontaine; Céline Marbœuf; Jean-Claude Brosse; Martine Maingault; Frédéric Dehaut
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 447 KB
- Volume
- 197
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
Hydrosoluble poly(3,6,9‐trioxaundecamethylene phosphonate) with attached cytotoxic bis(2‐chloroethyl)amine in the side chain was synthesized by chemical modification of the corresponding polyphosphonate via the Atherton‐Todd reaction. The structure of the product was confirmed by ^1^H, ^13^C and ^31^P NMR spectroscopy. Preliminary in vitro cytotoxic studies revealed that the polymeric derivative exhibited an eight fold more cytotoxic potency against human hepatocellular carcinoma cell line HepG2 than against murine leukemia cell line L1210.