Five-year follow-up results of a collaborative study of therapies for carcinoma of the bladder

✍ Scribed by Dr. Nelson H. Slack; Irwin D. J. Bross; George R. Prout Jr.

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 778 KB
• Volume: 9
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930090410

✦ Synopsis

Abstract

Results after 5 years of follow‐up in a cooperative trial of therapies for operable bladder cancer confirmed preliminary indications of a beneficial effect of preoperative irradiation. Improved survival was experienced by the one‐third of the irradiated patients who experienced complete eradication of the tumor as indicated from the resected specimen 30–60 days after a 30‐day course of 4,500 rads. These patients fiad a 55% chance of surviving 5 years as opposed to a 32% chance for those where irradiation did not eradicate the tumor, or similarly for those not irradiated. A postoperative course of chemotherapy with 5‐fluorouracial appeared to act detrimentally when given to patients irradiated preoperatively, but may have had a slight benefit when given after surgery alone.