Five new steroids from Solanum nudum

✍ Scribed by Jairo Saez; Wilson Cardona; Diego Espinal; Silvia Blair; Jacqueline Mesa; Mamadou Bocar; Akino Jossang

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 399 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00632-2

✦ Synopsis

Five new steroids, the cholest-4-ene-3,22-diones : tumacone A (1), tumacone B (2), tumacoside A (3), tumaeoside B (4), and a furustenone : tumaquenone (5), besides diosgenone (6), were isolated from the aerial parts of Solanum nudum. Their structures were determined by 2D NMR, MS analyses and chemical correlations. Steroid 3 and 5 displayed in v/fro antimalarial activity against a Plasmodium falciparum chloroquine-resistant FCB-1 strain (IC50 27 and 16 I~1). The observed stereodepandent eyelization into spiroketals of two 16-O isomers is disetis~ag~d.