✦ LIBER ✦

FISH in prenatal diagnosis

✍ Scribed by Michael L. Begleiter; Holly A. Ishmael

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 33 KB
Volume: 20
Category: Article
ISSN: 0197-3851
DOI: 10.1002/1097-0223(200008)20:8<686::aid-pd870>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

In our paper we presented a simple tabulation of the published results we judged to be valid, together with a weighted average of the fetal loss rates, to provide an indication of the summary estimates (43% after CVS and 23% after amniocentesis). The fact that they are in agreement with Cuckle's `informal synthesis', suggesting ranges of 45% to 46% fetal loss after CVS and 22% to 24% after amniocentesis, is gratifying. We believe, however, that a quantitative approach based on speci®c studies is more defensible than an individual's view, even if they are consistent. We agree that the actuarial method may be the one that turns out to be the most accurate and can be used on the accumulating data from the National Down syndrome cytogenetic register.

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