✦ LIBER ✦

First year serologic response to treatment for syphilis: a model for prediction of seroreversion

✍ Scribed by M. Sarah Rose; Gordon H. Fick; Barbara Romanowski; Edgar J. Love

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 158 KB
Volume: 16
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19970930)16:18<2103::aid-sim640>3.0.co;2-h

No coin nor oath required. For personal study only.

✦ Synopsis

There is no straightforward test available, within weeks of treatment for syphilis, to assess adequacy of serologic response. We propose a method to predict non-treponemal seroreversion based on short term response. To develop and illustrate this method, we used data from 370 individuals with infectious syphilis. Individual serologic response appears to be a linear function of (log) time, suggesting the possibility of using rapid plasma reagin titres recorded in the first few months after treatment to determine the slope of the linear treatment response line. The slope of the response line, during the first year after treatment, is an important predictor of seroreversion but must be considered in conjunction with pre-treatment titre. We recommend development of an action line be developed based on these variables. Such a line would indicate the necessity for retreatment if the line plotted from the patient's first year response failed to fall below the action line.

📜 SIMILAR VOLUMES

ASSESSMENT OF LACK OF FIT IN SIMPLE LINE

ASSESSMENT OF LACK OF FIT IN SIMPLE LINEAR REGRESSION: AN APPLICATION TO SEROLOGIC RESPONSE TO TREATMENT FOR SYPHILIS

✍ M. SARAH ROSE; GORDON H. FICK 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 385 KB 👁 2 views

A patient treated for infectious syphilis is cured when serologic tests become non-reactive, which may take years to achieve. Our objective is to develop a method to determine, within months, whether the patient has responded adequately to treatment. Previous research and our exploratory graphical a

A logistic model based on enzyme activit

A logistic model based on enzyme activities for the prediction of response of breast cancer patients to chemotherapy

✍ Russell Hilf; Michael L. Feldstein; Scott L. Gibson; Edwin D. Savlov 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB 👁 2 views

AN ANALYTICAL MODEL FOR THE PREDICTION O

AN ANALYTICAL MODEL FOR THE PREDICTION OF THE VIBRATION RESPONSE OF ROLLING ELEMENT BEARINGS DUE TO A LOCALIZED DEFECT

✍ N. Tandon; A. Choudhury 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 234 KB

An analytical model has been proposed for predicting the vibration frequencies of rolling bearings and the amplitudes of significant frequency components due to a localized defect on outer race, inner race or on one of the rolling elements under radial and axial loads. The model predicts a discrete

Carcinogenic chemical-response “fingerpr

Carcinogenic chemical-response “fingerprint” for male F344 rats exposed to a series of 195 chemicals: Implications for predicting carcinogens with transgenic models

✍ F.M. Johnson 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 2 views

Transgenic model systems have recently been advocated as replacements for traditional methods of testing chemicals for carcinogenicity in rodents. To shed light on the diversity of responses induced by chemicals in natural whole animal systems, a type of "fingerprint" is devised and, in turn, applie

Relation of mucous membrane alterations

Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer

✍ Barbara Roa Pauloski; Alfred W. Rademaker; Jerilyn A. Logemann; Donna Lundy; Mic 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 1 views

## Abstract ## Background. Acute oral mucositis is associated with pain and impaired swallowing. Little information is available on the effects of chronic mucositis on swallowing. ## Methods. Sixty patients treated for cancer of the head and neck were examined during the first year after their c

A Resonance Model gives the Response to

A Resonance Model gives the Response to Membrane Potential for an Ion Channel: II. Simplification of the Calculation, and Prediction of Stochastic Resonance

✍ AYOWUMI FATADE; JERRY SNOWHITE; MICHAEL E GREEN 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 155 KB

In a previous communication (Green, 1998), the initial step in ion channel gating for voltagegated channels was attributed to the tunneling of a proton between groups with similar pK values, under the in#uence of an electric "eld. This is in contrast to the standard thermally activated model, which