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First unequivocal observation of the multiple fully extended conformation (25-helix) in a homopeptide from a Cα-methylated chiral α-amino acid

✍ Scribed by André Aubry; Valerio Duca; Monica Pantano; Fernando Formaggio; Marco Crisma; Claudio Toniolo; Johan Kamphuis

Book ID
104627706
Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
388 KB
Volume
1
Category
Article
ISSN
1573-3149

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✦ Synopsis

An X-ray diffraction analysis of pBrBz- [D-(c~Me)Leu]3-OtBu revealed that in the crystal state this terminally blocked tripeptide adopts a multiple fully extended conformation (25-helix). This is the first unequivocal observation of such a structure in a homopeptide from a C%methylated chiral c~-amino acid. No intermolecular NH"O=C Hbonds are seen in the crystal packing.

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