In a study of 130 ยฎrst trimester cases of trisomy 21 and 959 controls we have shown that the median MoM for alpha-fetoprotein (AFP) is lower (0.82) and that for total human chorionic gonadotrophin (hCG) is higher (1.31) than in the control group. For AFP 15.3% of cases were below the 5th centile and
First trimester markers of trisomy 21 and the influence of maternal cigarette smoking status
โ Scribed by Kevin Spencer; Charas Y. T. Ong; Adolfo W. J. Liao; Demetres Papademetriou; Kypros H. Nicolaides
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 47 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0197-3851
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The aim of this study was to evaluate the feasibility of first-trimester biochemical screening for trisomy 18, by using pregnancy-associated plasma protein A (PAPP-A) and free beta human chorionic gonadotropin (hCG) in combination with maternal age. Maternal serum levels of PAPP-A and free beta-hCG